Posttranslational regulation of human DNA polymerase

Abstract

Background: Many proteins are subject to posttranslational regulation, such as ubiquitination. Results: Human DNA polymerase ι (polι) can be monoubiquitinated at >27 unique sites, and exposure to naphthoquinones results in polyubiquitination of polι. Conclusion: Ubiquitination sites are located across the entire polι polypeptide as well as various structural motifs. Significance: Ubiquitination at these sites is likely to alter cellular functions of polι in vivo.