Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.
CITATION STYLE
Fletcher, O., & Kessling, A. M. (1998). MTHFR association with arteriosclerotic vascular disease? Human Genetics, 103(1), 11–21. https://doi.org/10.1007/s004390050776
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