Constituents of the pericarps of Mallotus japonicus (Euphorbiaceae)

Abstract

Rottlerin-like phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus MUELL. ARG. (Euphorbiaceae) are reviewed. Chemical structures, cytotoxicity, antitumor and antitumor-promoting effects, antiviral activity, anti-HIV-RT activity, and inhibitory activity of activated macrophages (inhibitory activities of NO, prostaglandin E2, tumor necrosis factor-α, and interleukin-6 production) of the phloroglucinol derivatives are described. © 2003 The Pharmaceutical Society of Japan.