Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.
CITATION STYLE
Palladino, G., Nicolia, V., Kovacs, G. G., Canterini, S., Ciraci, V., Fuso, A., … Fiorenza, M. T. (2017). Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease. Journal of Molecular Neuroscience, 61(3), 359–367. https://doi.org/10.1007/s12031-016-0865-x
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