Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles

Abstract

The antiviral activity of a new class of N,N,N',N'',N'''-pentakis (ω- aminoalkyl) tetraazamacrocycles was evaluated in primary duck hepatocyte cultures infected with the duck hepatitis B virus (DHBV). Three of the four tested compounds were able to selectively inhibit DHBV replication by acting at an early step of the hepadnavirus infection but were associated with significant toxicity.