Advances in sequencing technologies have aided the discovery of millions of genome-wide DNA polymorphisms such as single-nucleotide polymorphisms (SNPs) and insertion-deletions (InDels) which are an invaluable resource for marker-assisted breeding. Presently available bioinformatics tools assist the discovery of polymorphisms between target genotypes and the reference genome for a range of species. The discovery of polymorphisms between two genotypes within a breeding program is complicated by several factors such as bias in the number of reads from each genotype and residual heterozygosity within each genotype. In this chapter, we describe a novel approach where polymorphisms between a pair of genotypes are discovered from whole-genome re-sequencing data. © 2014 Springer Science+Business Media, New York.
CITATION STYLE
Gopala Krishnan, S., Waters, D. L. E., & Henry, R. J. (2014). A method for discovery of genome-wide SNP between any two genotypes from whole-genome re-sequencing data. Methods in Molecular Biology, 1099, 287–294. https://doi.org/10.1007/978-1-62703-715-0_24
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