Anredera cordifolia leaves fraction as an antihyperlipidemia

Abstract

Objective: The objective of this research was to evaluate the reduction of blood cholesterol level by fraction extracts of binahong (Anredera cordifolia) on male Wistar rats. Methods: The rats were given high-fat food every day for 3 months and pure cholesterol on week 0, 3, 7, and 11. After that, each binahong fraction (n-hexane fraction, ethyl acetate fraction, and water fraction) with doses of 50 mg/kg bw, 100 mg/kg bw, and 200 mg/kg bw was given orally for 3 weeks and observed for lipid profile on day 21. Results: The result showed that n-hexane, ethyl acetate, and water fractions of binahong leaves decreased total cholesterol, triglyceride, and low-density lipoprotein (LDL) level and did not influence the high-density lipoprotein (HDL) level. Meanwhile, statin decreased total cholesterol, triglyceride, and LDL level and increased HDL level. Conclusion: Ethyl acetate fraction of binahong leaves significantly reduced total cholesterol level, triglycerides, and LDL level compared to the negative control group (p<0.05) and had no influence in HDL level.