GPNLPerf: Robust 4d non-rigid motion correction for myocardial perfusion analysis

Abstract

Since the introduction of wide cone detector systems,CT myocardial perfusion has been an area of increased interest,for which non-rigid registration [NRR] is a key step to further analysis. We propose a novel motion management pipeline for perfusion data,GPNLPerf (Group-wise,non-local,NRR for perfusion analysis) centering on groupwise NRR using non-local spatio-temporal constraints. The proposed pipeline deals with the NRR challenges for 4D perfusion data and results in generating clinically relevant perfusion parameters. We demonstrate results on 9 dynamic perfusion exams comparing results quantitatively with ANTs NRR and also show qualitative results on perfusion maps.