An ayurvedic polyherbal formulation PDBT for dyslipidemia and prevention of coronary artery disease (CAD) in pre-diabetic individuals

Abstract

Pre-diabetes is a 'grey area' between normal and diabetes. Various studies have shown that pre-diabetic subjects who developed diabetes had higher triglyceride and cholesterol values at baseline. At the time of diagnosis of diabetes around half of the patients will show some evidence of coronary artery disease. Treating dyslipidaemia in pre diabetes condition can not only reduce the conversion rate to diabetes but also occurrence of coronary artery disease (CAD). The Purpose of present study was to see whether an Ayurvedic polyherbal formulation PDBT which contains water extracts of Guduchi (Tinospora cordifolia), Vijaysar (Pterocarpus marsupium), Gudmar (Gymnemma sylvestre), Karvellak (Momordica charantia) and Shunthi (Zinziber officinale) can reduce mild to moderate dyslipidaemia in Pre-diabetic state as compared to placebo. A double blind placebo controlled (Randomized Controlled Trial) RCT was conducted on 100 patients (50 in each group) having mean age 48.78 ± 10.098; for 6 months to see the effect of polyherbal formulation as compared to placebo in pre-diabetic individuals. A diagnostic criterion for pre-diabetes was set according American Diabetic Association (ADA) 2000. Cholesterol, High Density Lipoprotein (HDL), was done with Wyebenga and Pileggi's method / Bio-lab Kit. Triglycerides were estimated by enzymatic Kit method. Blood sugar level (BSL) was calculated by Glucose oxidase- peroxidase (GOD-POD) method. Low Density lipoprotein (LDL), Very Low Density Lipoprotein (VLDL) was calculated by formula. These investigations were done before treatment (BT) and after treatment (AT). Unpaired T and paired T test were applied by INSTAT 2 software as a test of significance. Mean Cholesterol before treatment and after treatment 200.04 ± 41.6 and 172.09 ± 42.29, Mean HDL before treatment and after treatment 44.544 ± 10.517 and 47.30 ± 8.35, Mean LDL 116.37 and 92.91. Triglycerides before treatment and A. T. 160.16 ± 132.02 in PDBT treated group. While in placebo treated group these values were increased from 170.53 ± 32.05 to 191.62 ± 36.75, for Cholesterol before treatment and after treatment. LDL increased from 92.85 ± 31.19 to 99.139 for LDL. While for triglycerides values increased from 165.75 ± 44.33 to 211.18 ± 46.7.