Asynchronous computation with molecular reactions

Abstract

Mass-action kinetics of chemical reaction networks (CRNs) is powerful to describe computations through transfers of chemical concentrations. Here we present methods for asynchronously implementing digital signal processing (DSP) operations such as filtering with CRNs. We first review an implementation of DSP operations using molecular reactions based on a three-phase transfer scheme. This is an example of a locally asynchronous, globally synchronous implementation. We then present a fully asynchronous method that transfers signals based on absence of other signals. We illustrate our methodology with the design of finite impulse response (FIR) filters. The computation is exact and independent of specific reaction rates. Although conceptual for the time being, the proposed methodology has potential applications in domains of synthetic biology such as biochemical sensing and drug delivery. © 2011 IEEE.