The role of oral supplementation with immunonutrients in the inflammatory response in patients with COVID-19

  • Pimentel R
  • Merces M
  • Silva D
  • et al.
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Abstract

Introduction: The SARS-CoV-2 related coronavirus has spread to almost every country, causing the COVID-19. The severity of COVID-19 is based on the inflammation caused by the cytokine storm. Inflammatory markers suggest a molecular explanation for the occurrence of severe disease and represent a possible treatment. Objective: This review aims to analyse the plausibility of using oral supplementation with immunonutrients. Discussion: Immunonutrition studies the interactions between nutrition, the immune system, infection, and inflammation of tissues. Arginine is a fundamental amino acid in processes of metabolic stress. Its deficiency implies in the capacity of immune response. ω-3 fatty acids demonstrated improved lung compliance, oxygenation, mechanical ventilation time and intensive care unit stay in patients with acute respiratory distress syndrome. Essential for cell-mediated immunity and T lymphocyte function, dietary nucleotides have been shown to improve the cytotoxicity of natural killer cells. Considering that the inversely proportional relationship between presence of IL-6 and TNF-α and the function of T cells is well established in patients with COVID-19, this reinforces the idea that the release control of these biomarkers can be a way to treat this disease. Conclusion: In this scenario, this review raises the possibility of using immunonutrition to improve immune response of individuals affected by COVID-19.

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Pimentel, R. F. W., Merces, M. C. das, Silva, D. A. R. da, Souza, M. C. de, Cerqueira, M. M. B. da F., Figueiredo, P. C. M. de, … Sousa, A. R. de. (2020). The role of oral supplementation with immunonutrients in the inflammatory response in patients with COVID-19. Research, Society and Development, 9(9), e126997115. https://doi.org/10.33448/rsd-v9i9.7115

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