A disintegrin and metalloprotease (ADAM): Historical overview of their functions

Citations of this article
Mendeley users who have this article in their library.


Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane‐anchored metalloprotease‐disintegrin implicated in fertilization, almost three decades of studies have identified additional members of these families and several biochemical mechanisms regulating their expression and activity in the cell. Most importantly, new in vivo functions have been recognized for these proteins including cell partitioning during development, modulation of inflammatory reactions, and development of cancers. In this review, we will overview the a disintegrin and metalloprotease (ADAM) family of proteases highlighting some of the major research achievements in the analysis of ADAMs’ function that have underscored the importance of these proteins in physiological and pathological processes over the years.

Author supplied keywords




Giebeler, N., & Zigrino, P. (2016, April 23). A disintegrin and metalloprotease (ADAM): Historical overview of their functions. Toxins. MDPI AG. https://doi.org/10.3390/toxins8040122

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free