Controlled release of atenolol from freeze/thawed poly(vinyl alcohol) hydrogel

Abstract

Physically crosslinked polymeric films containing atenolol drug were formulated and the release of the drug was evaluated with view to investigate the feasibility of these films as drug delivery systems. Freezing and thawing process for PVA was used to prepare a controlled release device for atenolol drug. The process included incorporation of the drug into PVA film during the freezing and thawing process. The PVA has used a molecular weight of 125 k and degree of saponification of 98. Various amounts of the atenolol drug were incorporated into the freeze/thawed PVA. The in vitro release behavior of atenolol from these films was investigated. The drug release profiles from the polymeric formulations indicated initial high rate of release followed by slow rate of the release. The release of atenolol increased with increasing drug concentration in the film. The results showed the feasibility of the use of freezing and thawing technique to control the release of atenolol drug from PVA. © 2010.