Abstract
A novel potent and selective kynurenine-3-hydroxylase inhibitor is descibed along a preliminary evaluation in a in vivo gerbil model of its ability to increase the kynurenine and kynurenic acid concentration in both plasma and brain. These data support the notion that kynurenine-3-hydroxylase inhibitors may have a sustained therapeutic potential in those diseases characterized by unbalance in the QUIN /KYNA branches of the kynurenine pathway.
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CITATION STYLE
Pellicciari, R., Amori, L., Costantino, G., Giordani, A., Macchiarulo, A., Mattoli, L., … Varasi, M. (2003). Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. In Advances in Experimental Medicine and Biology (Vol. 527, pp. 621–628). Kluwer Academic/Plenum Publishers. https://doi.org/10.1007/978-1-4615-0135-0_71
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