4-Hydroxy-2-quinolones. 16. Condensation of N-R-substituted amides of 2-carboxymalonanilic acid with o-phenylenediamine

Abstract

The reaction of N-R-substituted amides of 2-carboxymalonanilic acid with the equimolar amount of o-phenylenediamine was studied under conditions of thermolysis. It was established that the main products of this reaction are the corresponding amides of benzimidazolyl-2-acetic acid and 1H-2-oxo-3-(benzimidazolyl-2)-4-hydroxyquinoline. Mechanisms of the indicated chemical conversions are discussed. The data on the study of the anticonvulsive activity of the compounds synthesized are presented. © 1994 Plenum Publishing Corporation.