0652 HEALTH-RELATED QUALITY OF LIFE IN NARCOLEPSY AND IDIOPATHIC HYPERSOMNIA

Abstract

Introduction: The reported lower health-related quality of life (HRQOL) in hypersomnia disorders using small clinical populations has made comparisons between disorders challenging. The aim of the current study was to compare HRQOL in adult patients with Narcolepsy Type 1 (NT1), Narcolepsy Type 2 (NT2), and Idiopathic Hypersomnia (IH) through an online survey. Methods: Participants with NT1, NT2, and IH answered the Veterans RAND 36-Item Health Survey (VR-36) assessing eight HRQOL domains (PF, physical functioning; RP, role physical; RE, role emotional; BP, body pain; GH, general health; VT, vitality; MH, mental health; SF, social functioning) and two standardized composite scales (PCS, physical; MCS, mental). The VR-36 was part of an anonymous survey in 2015, the Boston University Narcolepsy and Idiopathic Hypersomnia Patient Perspectives Study (BUNIHPPS). Analysis of variance was performed to assess between-group differences, and when significant (p < 0.05), Tukey's post hoc tests were performed while adjusting for age, gender, body mass index, number of comorbidities, and hypersomnia medication use. Results: 833 participants completed the survey (338 NT1, 210 NT2, and 285 IH). Participants were predominantly female (706 females, 126 males) and on average 40 years. Mean PCS and MCS scores for hypersomnia patients were one standard deviation below the normative United States population mean scores. Adjusted mean scores indicated between-group differences (PCS: F 7, 700 = 9.93, p < 0.0001; MCS: F 7, 700 = 3.51, p = 0.0306). Adjusted mean PCS scores were significantly higher in NT2 compared to NT1/IH, whereas MCS scores were significantly higher for NT1 than NT2. IH scored significantly lower than one/both narcolepsy group(s) on PF, RP, GH, VT, and SF domains. NT2 scored significantly lower than NT1 on the MH domain. Conclusion: Lower physical and mental composite scale scores among hypersomnia patients suggests poorer functioning and the need for improved management options, including behavioral interventions and/or a more collaborative clinical approach. In our sample, IH was more compromised than NT1/NT2 in general health, social functioning, vitality, and physical health domains (PF/RP). NT2 reported more compromised mental health functioning (MH/MCS) despite having better physical functioning compared to NT1.