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Effect of adiponectin gene polymorphisms on waist circumference in patients with diabetes

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Background: Plasma levels of adiponectin which is secreted from adipose tissue are associated with various parameters of metabolic syndrome. This effect seems to be a result of interactions between genetic and environmental factors including central obesity. The present study was carried out to investigate the possibility of relation between single nucleotide polymorphisms of adiponectin gene (+45 T/G and -11391 G/A) and waist circumferences (WC) in patients with type 2 diabetes.Methods: This cross-sectional study was conducted on n = 238 diabetic patients selected as cases and n = 159 as healthy control who were recruited from Rafsanjan city in south - east of Iran. The possible association of +45 T/G and -11391 G/A adiponectin gene polymorphisms with WC according to age and sex was evaluated.Results: There was no significant difference in distribution of frequencies of +45 T/G and -11391 G/A adiponectin gene polymorphisms in each group. We only found a significant association between -11391 G/A adiponectin gene polymorphism with WC in diabetic group (p = 0.021). This association was remained significant after adjustment in multivariate regression model (p = 0.019, OR: 0.244, 95%CI: 0.075-0.791) and also this effect was independent of sex and age.Conclusion: We found higher abdominal obesity in GA or AA carriers of adiponectin - 11391 G/A genotype in type 2 diabetes patients independent of age and sex. © 2012 Hasani-Ranjbar et al.; licensee BioMed Central Ltd.




Hasani-Ranjbar, S., Amoli, M. M., Tabatabaei-Malazy, O., Rumi, Y., Tavakkoly-Bazzaz, J., Samimi, H., & Abbasifarid, E. (2012). Effect of adiponectin gene polymorphisms on waist circumference in patients with diabetes. Journal of Diabetes and Metabolic Disorders, 11(1).

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