Effect of adiponectin gene polymorphisms on waist circumference in patients with diabetes

11Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Background: Plasma levels of adiponectin which is secreted from adipose tissue are associated with various parameters of metabolic syndrome. This effect seems to be a result of interactions between genetic and environmental factors including central obesity. The present study was carried out to investigate the possibility of relation between single nucleotide polymorphisms of adiponectin gene (+45 T/G and -11391 G/A) and waist circumferences (WC) in patients with type 2 diabetes.Methods: This cross-sectional study was conducted on n = 238 diabetic patients selected as cases and n = 159 as healthy control who were recruited from Rafsanjan city in south - east of Iran. The possible association of +45 T/G and -11391 G/A adiponectin gene polymorphisms with WC according to age and sex was evaluated.Results: There was no significant difference in distribution of frequencies of +45 T/G and -11391 G/A adiponectin gene polymorphisms in each group. We only found a significant association between -11391 G/A adiponectin gene polymorphism with WC in diabetic group (p = 0.021). This association was remained significant after adjustment in multivariate regression model (p = 0.019, OR: 0.244, 95%CI: 0.075-0.791) and also this effect was independent of sex and age.Conclusion: We found higher abdominal obesity in GA or AA carriers of adiponectin - 11391 G/A genotype in type 2 diabetes patients independent of age and sex. © 2012 Hasani-Ranjbar et al.; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Hasani-Ranjbar, S., Amoli, M. M., Tabatabaei-Malazy, O., Rumi, Y., Tavakkoly-Bazzaz, J., Samimi, H., & Abbasifarid, E. (2012). Effect of adiponectin gene polymorphisms on waist circumference in patients with diabetes. Journal of Diabetes and Metabolic Disorders, 11(1). https://doi.org/10.1186/2251-6581-11-14

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free