DNA-encoded library (DEL) links the powers of genetics and chemicals via high-efficient enzymatic ligation of DNA barcodes and the “split and pool” combinatorial synthesis. Natural products (NPs) are evolutionary optimized compounds that have played a key role in the history of human drug discovery. Herein, we describe a method for functionality-independent annotation of complex natural products with amplifiable DNA barcodes to generate a DNA-encoded natural product library (nDEL). This method provides a simple and practical solution to leverage natural products by DNA barcoding.
CITATION STYLE
Xu, H., & Ma, P. (2022). DNA Encoding of Natural Products. In Methods in Molecular Biology (Vol. 2541, pp. 81–87). Humana Press Inc. https://doi.org/10.1007/978-1-0716-2545-3_13
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