Spontaneous regression of methotrexate-related lymphoproliferative disorder with T-cell large granular lymphocytosis

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Abstract

Spontaneous regression of methotrexate-related lymphoproliferative disorders (MTX-LPDs) occurs in some patients after withdrawal of MTX. However, the mechanisms by which MTX withdrawal contributes to the spontaneous regression of MTX-LPDs have not been fully elucidated. We herein show that spontaneous regression of MTX-LPDs is associated with the development of significant and transient T-cell large granular lymphocyte (T-LGL) lymphocytosis induced by MTX withdrawal. Since T-LGLs show strong cytotoxicity, their expansion may contribute to the spontaneous regression of lymphoma. Therefore, the development of TLGL lymphocytosis maybe associated with a favorable prognosis in MTX-LPD patients.

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Ureshino, H., Kadota, C., Kurogi, K., Miyahara, M., & Kimura, S. (2015). Spontaneous regression of methotrexate-related lymphoproliferative disorder with T-cell large granular lymphocytosis. Internal Medicine, 54(17), 2235–2239. https://doi.org/10.2169/internalmedicine.54.4207

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