Lipids and membrane proteins are the main components of cell membranes. Lipid-protein interactions are dynamic because these interactions typically occur on shallow protein surface clefts. Molecular dynamics (MD) simulations provide a tool for studying the dynamics of these interactions. Here, we describe the interactions of phosphatidylinositol-4,5-bisphosphate (PIP2) with both the open and closed states of a KCNQ2 channel. Through these methods, we show that a lipid can migrate between different binding sites in a protein and this migration modulates protein functions.
CITATION STYLE
Zhang, Q., & Yang, H. (2018). Migration of PIP2 on KCNQ2 surface revealed by molecular dynamics simulations. In Methods in Molecular Biology (Vol. 1684, pp. 151–161). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7362-0_12
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