OBJECTIVE: Evaluate the expression of KI-67 in uterine leiomyomas and adjacent myometrial tissue and verify the existence of a correlation between clinical parameters and KI-67 expression in tumors. METHODS: This is a cross-sectional, controlled, analytical study. Samples of leiomyomas and myometrium were obtained from patients who underwent hysterectomy. The samples were processed by immunohistochemistry using KI-67 antibody, and the expression was evaluated by two blinded observers. Student's T-test was used for comparison of means, and Pearson's P test for correlation with clinical parameters. RESULTS: A total of 9 patients were included in the study. The mean age was 40.7 years, ranging from 35 to 44 years. The mean expression of KI-67 in myometrium was 1.63%, and, in leiomyomas, 5.96% (p <0.001). The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level. CONCLUSION: The expression of KI-67 in normal myometrium was significantly lower than in leiomyomas. The highest expression of KI-67 was moderately related to the severity of anemia, bleeding, and pain level in the patients of this study.
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Filho, W. M. N. E., Soares, E. A. S., Lima, M. S. O., do Nascimento Brazil, E. D., de Melo Rodrigues, R. M., Zeron, R. M. C., … Costa, P. V. L. (2019). Evaluation of KI-67 expression in uterine leiomyoma and in healthy myometrium: A pilot study. Revista Da Associacao Medica Brasileira, 65(12), 1459–1463. https://doi.org/10.1590/1806-9282.65.12.1459
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