Wound Healing and Blood Sugar Effect of Psidium guajava L. Leaves and Melastoma malabathricum L. Leaves on Rats with Diabetic Foot Ulcer

Abstract

Background and Objective: Approximately 15% of people with DM will experience ulcers during their illness and 3-4% will have severe infections. This study aimed to examine the wound healing and blood sugar effect of Psidium guajava L. and Melastoma malabathricum L. (senduduk) leaves using diabetic foot ulcer rats. Materials and Methods: Diabetes were induced in the rat by single kgG1 ) and was injured by excision. The 30 rats were divided into following intraperitoneal injection of Alloxan monohydrate (120 mg kgG1 ) group: untreated control (group 1), group treated with metformin (group 2), group treated with senduduk leaves extract (group 3), group treated with guava leaves extract (group 4) and group treated with mixed extract of senduduk leaves and guava leaves (group 5). Blood sugar levels and wound area were measured before and after the intervention. Results: In vitro, the bioactive components of the mixed and high antioxidant activity >31.25 ppm extract found were Flavonoid, Tannin, Saponin Steroid, total phenol 6.08%, quercetin 0.31 m gG1 in the mixed extract. In vivo analysis of rat group with mixed extract of senduduk leaves and guava leaves significantly (p<0.05) was able to decrease blood glucose level and reduce wound area in rat's foot and was better than other groups. Conclusion: Senduduk leaf extract and guava leaf extract significantly (p<0.05) reduce blood glucose levels and reduce the area of injury in rat feet.