The relationship between the serum level of selenium and cervical intraepithelial neoplasia: A comparative study in a population of Nigerian women

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Abstract

Objective: To determine the relationship between the serum level of selenium and cervical intraepithelial neoplasia (CIN). Methods: A case controlled study that compared the serum level of selenium in 45 women with CIN (cases) to 45 women (age matched controls) with normal cervical cytology. Socio-demographic data and information on known risk factors for cervical cancer among the sample was compared between both groups using inferential statistics. Results: There was no significant difference in the mean selenium values between the cases and controls [p- 0.076, 95% CI (-15.08 - 0.76)]. However, subgroup analysis showed a statistically significant difference between patients with normal cervical cytology, CIN I, II and III (p= 0.021). In addition, there was also significant difference in the selenium level between women with normal cervical cytology and CIN III (p value = 0.016) with a significant inverse linear trend (p= 0.025). Conclusion: With increasing severity of CIN, a significant reduction in the level of selenium in serum was observed. This reducing value of serum selenium, a surrogate marker for increased oxidative stress, may be important factor for the development of persistent HPV infection and in particular high grade CIN III lesions. This observation requires further research.

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Obhielo, E., Ezeanochie, M., Oghenefegor Olokor, O., Okonkwo, A., & Gharoro, E. (2019). The relationship between the serum level of selenium and cervical intraepithelial neoplasia: A comparative study in a population of Nigerian women. Asian Pacific Journal of Cancer Prevention, 20(5), 1433–1436. https://doi.org/10.31557/APJCP.2019.20.5.1433

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