Photochemistry of highly organized biomolecules: Sequence-selective photoreaction of DNA

Abstract

Two types of highly sequence-selective photoreactions of DNA are described. One example includes a specific photocleavage of DNA duplex at 5’ side of 5'-GG-3’ sequence by a ’’photo-Fenton reagent”, whereas the other is the sequence-selective photoreaction of 5'-ABrU- site of DNA duplex which results in formation of a 2-deoxyribonolactone residue with release of free adenine via selective hydrogen abstraction from C2’ of deoxyribose residue. © 1992, IUPAC