The active spatial organization of the β-globin locus requires the transcription factor EKLF

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Abstract

Three-dimensional organization of a gene locus is important for its regulation, as recently demonstrated for the β-globin locus. When actively expressed, the cis-regulatory elements of the β-globin locus are in proximity in the nuclear space, forming a compartment termed the Active Chromatin Hub (ACH). However, it is unknown which proteins are involved in ACH formation. Here, we show that EKLF, an erythroid transcription factor required for adult β-globin gene transcription, is also required for ACH formation. We conclude that transcription factors can play an essential role in the three-dimensional organization of gene loci.

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Drissen, R., Palstra, R. J., Gillemans, N., Splinter, E., Grosveld, F., Philipsen, S., & De Laat, W. (2004). The active spatial organization of the β-globin locus requires the transcription factor EKLF. Genes and Development, 18(20), 2485–2490. https://doi.org/10.1101/gad.317004

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