Factors Associated with Sarcopenia in Patients with Chronic Kidney Disease: A Cross-Sectional Single-Center Study

Abstract

BACKGROUND Sarcopenia is a recognized complication of chronic kidney disease (CKD) and increases risk of increased morbidity from cardiovascular events and mortality. This single-center cross-sectional study aimed to determine the prevalence and factors associated with sarcopenia in CKD patients. MATERIAL AND METHODS Patients with non-dialysis-dependent (NDD)-CKD were examined for sarcopenia by handgrip strength testing, bioelectrical impedance analysis (BIA), and 4-minute gait speed test. We divided 220 patients into 2 groups - No Probable Sarcopenia (NPS; n=120) and Probable Sarcopenia (PS; n=100) - according to muscle strength defined by handgrip strength, then into another 2 groups - No Sarcopenia (NS; n=189) and Confirmed Sarcopenia (CS; n=31) - according to muscle mass defined by BIA. RESULTS Mean age and prevalence of coronary heart disease were significantly higher and mean body mass index (BMI) was lower in the PS and CS groups than that of NPS and NS groups (P.