Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma

Abstract

Background: The purpose of this study was to evaluate the prognostic value of magnetic resonance imaging (MRI)-detected cranial nerve (CN) involvement in nasopharyngeal carcinoma (NPC), METHODS: Retrospective analysis was made of the magnetic resonance images and medical records of 924 consecutive patients with newly diagnosed NPC. RESULTS: Of 924 patients. 82 (8.9%) initially presented with CN palsy. CN involvement was seen on MRI in 333 (36%) patients. In T3-4 disease. MRI-evidenced CN involvement was associated with poor 3-year overall survival (OS) (35.7% vs 89.2%. P=.001) and distant metastasis-free survival (DMFS) (77.1% vs 87.8%. P =.002) rates. The survival curves of OS and DMFS for T3 disease with MRI-detected CN involvement approximated those of T4 disease (P=.322 and P =.809, respectively). In patients with MRI-detected CN involvement, no significant differences were observed in 3- year OS (78.3% vs 72.9%. P=.120), local relapse-free survival (LRFS) (89.7% vs 84.1%. P=.154), or DMFS (79.6% vs 74.8%. P=.466) rates between those with and without intracranial or orbital CN involvement. Furthermore, in patients with clinical and/or MRI-detected CN involvement, there were no significant differences in the 3-year OS (74.2% vs 80.1%, P =.067), LRFS (86.7% vs 87.9%, P=.899), or DMFS (74.6% vs 84.6%. P=.094) rates between symptomatic and asymptomatic patients. CONCLUSIONS: The incidence of MRI-detected CN involvement was higher than CN palsy. MRI-detected CN involvement has a negative impact on the prognosis independent of lesion localization and symptoms. © 2009 American Cancer Society.