Adjuvant -Lactam therapy combined with vancomycin for methicillin-resistant staphylococcus aureus bacteremia: Does -lactam class matter?

Abstract

We analyzed the impact of vancomycin (VAN) combined with adjuvant -lactam therapy (Combo) on persistent (5 days) methicillin-resistant Staphylococcus aureus bacteremia versus VAN alone by using pooled data from two previously published observational studies (n 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9% and 7.6%, respectively; P 0.062).