Retinoic acid receptor γ (Rarg) and nuclear receptor subfamily 5, group a, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons

Abstract

Background: It is necessary to identify more factors to increase fibroblast to neuron conversion with non-integration adenovirus. Results: Nuclear receptor Rarg and Nr5a2 or agonist greatly enhance the conversion efficiency. Conclusion: Rarg and Nr5a2 both promote transdifferentiation and improve neuronal function. Significance: It would be of potential advantage to obtain safe and functional neurons with high efficiency. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.