MOLECULAR DOCKING OF PHYTOCHEMICALS AGAINST BREAST CANCER: A REVIEW

Abstract

There is a huge hike in the prevalence of cancer worldwide. Breast cancer is one of the widespread types of cancer and in terms of occurrence it has been ranked in the top first cancer types. Different cancer treatment methods cause high side effects in patients. A large number of isolated natural compounds have been reported to possess anticancer properties; the mechanisms of their action are not well understood. Different phytochemicals can be utilized for the treatment of breast cancer because of their wide safety nature and ability to target heterogeneous populations of cancer cells. Docking is a key tool in novel drug design and discovery. Inhibiting various receptors of breast cancer is an important therapeutic option. Protein target includes ERα, PR, EGFR, HER-2, etc. The 3D structures of these target proteins were obtained from the protein data bank. The complementarily of ligand and a protein target at the molecular level can be determined through In silico docking techniques. Protein-ligand docking concepts have applications such as structure-based drug design (SBDD), lead Optimization, evaluation of biochemical pathways and in De Novo drug design. Conclusion: In this review, an effort has been made to analyze the docking of potent phytochemicals against breast cancer target proteins. Keywords