Abstract
Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.
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Tischner, D., Woess, C., Ottina, E., & Villunger, A. (2010). Bcl-2-regulated cell death signalling in the prevention of autoimmunity. Cell Death & Disease. https://doi.org/10.1038/cddis.2010.27
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