Seeing the forest for the trees: Kidney oncogenomes in relation to therapeutic outcomes

Abstract

Renal cell carcinoma is a heterogeneous disease, and tissue investigations provide clues that may predict treatment response. Oncogenomic analysis of five outliers, who achieved a sustained response with rapalogs, implicates alterations of the TSC1 and mTOR genes and reveals insights into the conserved evolution of tumors. ©2014 AACR.