Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled Extracellular signal-regulated Kinase (ERK) activation

Abstract

Background: Signaling pathways underlying beneficial effects of extracorporeal shock wave treatment (ESWT) remain to be completely elucidated. Results: ESWT enhances cell proliferation in vitro and wound healing in vivo. Significance: Deciphering the involved signaling cascades provides the basis for ESWT as clinical wound healing treatment. Conclusion: ESWT-induced ATP release and subsequent extracellular signal-regulated kinase (ERK) activation are prerequisites for enhanced cell proliferation and wound healing.