The RNA interference pathway: A new target for autoimmunity

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Many intracellular macromolecular complexes that are involved in the production or degradation of RNAs are targeted by auto-antibodies in systemic autoimmune diseases. RNA interference (RNAi) is a recently characterized gene silencing pathway by which specific mRNAs are either degraded or translationally suppressed. In a recent issue of Arthritis Research and Therapy, Andrew Jakymiw and colleagues reported that the enigmatic Su auto-antigen complex contains key components of the RNAi machinery. Anti-Su autoantibodies from both human patients with rheumatic diseases and a mouse model of autoimmunity recognize the endo-nucleolytic Argonaute and Dicer proteins, both crucial enzymes of the RNAi pathway. These data raise the question of how the anti-Su response is triggered. So far, it is unknown whether molecular modifications may be involved, as has been proposed for other intracellular autoantigens. The implication of RNAi in anti-viral defence may suggest a role for virus infection in this process. © 2006 BioMed Central Ltd.




Pruijn, G. J. M. (2006). The RNA interference pathway: A new target for autoimmunity. Arthritis Research and Therapy, 8(4).

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