Diagnosis of intrachromosomal amplification of chromosome 21 ( iAMP 21) by molecular cytogenetics in pediatric acute lymphoblastic leukemia

  • Duployez N
  • Boudry‐Labis E
  • Decool G
  • et al.
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Abstract

Intrachromosomal amplification of chromosome 21 ( iAMP 21) defines a distinct cytogenetic subgroup of B‐cell precursor acute lymphoblastic leukemia ( BCP ‐ ALL ) with poor prognosis that should be investigated in routine practice. Single‐nucleotide polymorphism ( SNP )‐array provides a useful method to detect such cases showing a highly characteristic profile.

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Duployez, N., Boudry‐Labis, E., Decool, G., Grzych, G., Grardel, N., Abou Chahla, W., … Roche‐Lestienne, C. (2015). Diagnosis of intrachromosomal amplification of chromosome 21 ( iAMP 21) by molecular cytogenetics in pediatric acute lymphoblastic leukemia. Clinical Case Reports, 3(10), 814–816. https://doi.org/10.1002/ccr3.357

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