IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis

  • Zepp J
  • Zhao J
  • Liu C
  • et al.
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Abstract

This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly reduced tumor development in an azoxymethane/DSS model of colitis-associated cancer. A novel IL-17A target gene, PLET1 (a progenitor cell marker involved in wound healing), was highly induced in DSS-treated colon tissues and tumors in an IL-17RC–dependent manner. PLET1 expression was induced in LGR5+ colon epithelial cells after DSS treatment. LGR5+PLET1+ marks a highly proliferative cell population with enhanced expression of IL-17A target genes. PLET1 deficiency impaired tissue repair of DSS-induced damage in colon epithelium and reduced tumor formation in an azoxymethane/DSS model of colitis-associated cancer. Our results suggest that IL-17A–induced PLET1 expression contributes to tissue repair and colon tumorigenesis.

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APA

Zepp, J. A., Zhao, J., Liu, C., Bulek, K., Wu, L., Chen, X., … Li, X. (2017). IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis. The Journal of Immunology, 199(11), 3849–3857. https://doi.org/10.4049/jimmunol.1601540

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