Emerging technologies to increase the bioavailability of poorly water-soluble drugs

Abstract

The need for novel processes and formulation-based techniques to enhance the solubility of poorly water-soluble drugs has increased substantially in recent years. This is primarily due to the limitations of traditional techniques such as physical and chemical stability of the drug substance or the need for toxic solvents that some techniques require. Alternative solubility-enhancement techniques have emerged in recent years to mitigate issues such as these. The purpose of this chapter is to describe emerging technologies for solubility enhancement, allowing the reader to gain an understanding of their utility.