Neuroimaging advances in stroke rehabilitation

Abstract

Human ischaemic stroke is a multistage disorder with various routes of recovery. Neuroimaging allows researchers to explore the pathophysiology and recovery mechanisms in vivo. Based on these findings, motor recovery and chronic motor impairment after stroke have been linked to structural alterations of grey and white matter as well as functional changes in the perilesional tissue. Parameters derived from diffusion tensor imaging and functional magnetic resonance imaging can be used as surrogate markers of chronic motor impairment and predictors of functional potential for motor recovery. These parameters have the potential to tailor individual rehabilitation and stratify patients for experimental therapy studies such as invasive and non-invasive brain stimulation alone or in combination with other facilitators. © TOUCH BRIEFINGS 2010.