Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure-activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity. Copyright © 2004 American Chemical Society.
CITATION STYLE
Tully, S. E., Mabon, R., Gama, C. I., Tsai, S. M., Liu, X., & Hsieh-Wilson, L. C. (2004). A chondroitin sulfate small molecule that stimulates neuronal growth. Journal of the American Chemical Society, 126(25), 7736–7737. https://doi.org/10.1021/ja0484045
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