A dammarane glycoside derived from ginsenoside Rb3

Abstract

A dammarane glycoside, designated compound Mx (C-Mx), was isolated from the hydrolysate of 20(S)-protopanaxadiol type ginsenosides containing G-Rb 3 from POHOX notoginseng leaves with crude snailase. Its chemical structure was elucidated to be 20-O-β-D-xylopyranosyl(1→6)-β-D- glucopyranosyl-20(S)-protopanaxadiol on the basis of spectral analysis. Its cytotoxicity against breast cancer cell line MCF-7 and effects on the sensitivity to doxocubicin of doxocubicin-resistant MCF-7 cells were also investigated. The new compound showed moderate cytotoxicity and partial reversal of doxocubicin resistance. © 2005 Pharmaceutical Society of Japan.