Adding Water to the Mill: Olmesartan-Induced Collagenous Sprue - A Case Report and Brief Literature Review

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Abstract

Collagenous sprue (CS) is a distinct clinicopathological disorder histologically defined by a thickened subepithelial band (Freeman, 2011). It is a rare condition which has been recently observed in a significant proportion of sprue-like enteropathy associated with olmesartan, a novel entity described by Rubio-Tapia et al. in 2012. CS is historically associated with a poor prognosis (Marthey et al., 2014). However, histological and clinical improvements have been described in most studies with concomitant usage of corticosteroids and/or gluten-free diet (Marthey et al., 2014). We report a unique case of olmesartan-induced collagenous sprue in a 79-year-old man that showed complete histological and clinical remission with the sole withdrawal of the incriminating drug. The literature on this topic is briefly reviewed.

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Desruisseaux, C., Bensoussan, M., Désilets, E., Tran, H. K., Arcand, R., Poirier, G., … Manière, T. (2016). Adding Water to the Mill: Olmesartan-Induced Collagenous Sprue - A Case Report and Brief Literature Review. Canadian Journal of Gastroenterology and Hepatology. Hindawi Limited. https://doi.org/10.1155/2016/4837270

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