Lipid and PLGA Microparticles for Sustained Delivery of Protein and Peptide Drugs

  • Wu C
  • Mu H
9Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Solid lipid particles have a great potential in sustained drug delivery, the lipid excipients are solid at room temperature with a slow degradation rate. Poly (D, L-lactic-co-glycolic acid) (PLGA) have been successfully clinically applied for the sustained delivery of peptide drugs. A recent study showed the advantage of hybrid PLGA-lipid microparticles (MPs) over PLGA MPs for sustained delivery of peptide drug in vivo. In this paper, we briefly present solid lipid MPs and PLGA MPs prepared by the double emulsion method and the spray drying method and discuss the effects of excipients on encapsulation efficiency of protein and peptide drugs in the MPs. The pros and cons of PLGA MPs and solid lipid MPs as carriers for sustained delivery of protein and peptide drugs are also discussed.

Cite

CITATION STYLE

APA

Wu, C., & Mu, H. (2019). Lipid and PLGA Microparticles for Sustained Delivery of Protein and Peptide Drugs. Pharmaceutical Nanotechnology, 8(1), 22–32. https://doi.org/10.2174/2211738507666191029160944

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free