Dynamics of the mucosa-associated flora in ulcerative colitis patients during remission and clinical relapse

Abstract

The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF for controls was stable over time. Copyright © 2008, American Society for Microbiology. All Rights Reserved.