Immune dysregulation diseases

Abstract

The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or improper response against self-antigens can result in autoimmunity. Various cells and mediator molecules are involved in the regulation of immune system. The complexity of this system makes it prone to many genetic defects resulting in increased susceptibility to infections and/or autoimmune disorders.