DNA-templated silver nanoclusters formation at gold electrode surface and its application to hydrogen peroxide detection

Abstract

In this work, we have prepared Ag nanoclusters (Ag NCs) at gold electrode surface by using thiol-modified oligodeoxynucleotide consisting of eighteen cytosine deoxyribonucleotides (polyC 18) as template and NaBH 4 as reducing agent. Experimental results show that Ag nanoclusters (Ag NCs) can be formed around the template polyC 18, while the formation can be characterized with electrochemical method. Further studies reveal that the fabricated Ag NCs may display high catalytic activity for the reduction of hydrogen peroxide (H 2O 2), which can be further used for the detection of H 2O 2. © 2012 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.