Arborcandins A, B, C, E and F, novel 1,3-β-glucan synthase inhibitors: Production and biological activity

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Abstract

Arborcandins A, B, C, D, E and F, which possess potent 1,3-β-glucan synthase inhibitory activity, were isolated from the culture broth of a filamentous fungus, strain SANK 17397. Arborcandins are novel cyclic peptides, that are structurally different from known glucan synthase inhibitors such as echinocandins. The 1,3-β-glucan synthase of Candida albicans and Aspergillus fumigatus were inhibited by arborcandins with IC50 ranging from 0.012 to 3 μg/ml. The apparent Ki value of arborcandin C for C. albicans and A. fumigatus were 0.12 μM and 0.016 μM, respectively. The inhibition against these two 1,3-β-glucan synthases by arborcandin C was noncompetitive. These compounds exhibited potent fungicidal activity against Candida spp. with MIC ranging from 0.25 to 8 μg/ml. The growth of A. fumigatus was suppressed by arborcandins with concentrations ranging from 0.063 to 4 μg/ml.

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Ohyama, T., Kurihara, Y., Ono, Y., Ishikawa, T., Miyakoshi, S., Hamano, K., … Inukai, M. (2000). Arborcandins A, B, C, E and F, novel 1,3-β-glucan synthase inhibitors: Production and biological activity. Journal of Antibiotics, 53(10), 1108–1116. https://doi.org/10.7164/antibiotics.53.1108

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