The generation of a strong antibody response to target antigens is a major goal for vaccine development. Here we describe the display of the human immunodeficiency virus (HIV) envelope spike protein (Env) on a virus-like scaffold provided by the lambda phage capsid. Phage vectors, in general, have advantages over mammalian virus vectors due to their genetic tractability, inexpensive production, suitability for scale-up, as well as their physical stability, making them an attractive vaccine platform.
CITATION STYLE
Mattiacio, J. L., Brewer, M., & Dewhurst, S. (2017). Display of HIV-1 envelope protein on lambda phage scaffold as a vaccine platform. In Methods in Molecular Biology (Vol. 1581, pp. 245–253). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6869-5_14
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