Regenerative potential of blood stem cell products used in hematopoietic stem cell transplantation

Abstract

In this chapter, we address the role of nonhematopoietic progenitors with regenerative potential that are present in blood stem cell grafts used in hematopoietic transplantation. In particular, we discuss the potential role of nonhematopoietic progenitors in reducing transplant-associated tissue toxicity. We discuss specific cell types including endothelial progenitors and mesenchymal stromal cells that may be associated with tissue repair, and we discuss some potential strategies for augmenting the regenerative capacity of blood stem cell products which could have more widespread applicability to a broad range of acute tissue injuries.