The phosphoinositide 3-Kinase pathway is crucial for the growth of canine mast cell tumors

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Abstract

Mast cell tumors (MCTs) are the most common tumors in dogs, accounting for 16-21% of cutaneous tumors. Although several small molecule inhibitors, including imatinib mesylate, have been used for the treatment of MCTs, the response rate remains less than 50%. In this study, the effects of different selective signal inhibitors on MCT cell growth were evaluated using 4 different cell lines derived from dogs. We found that the phosphoinositide 3-kinase (PI3K) signaling pathway is crucial for the proliferation of MCT cells in the presence or absence of c-kit gene mutations. Here, we propose a novel therapeutic strategy to target the PI3K pathway for the treatment of canine MCTs. © 2013 The Japanese Society of Veterinary Science.

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Amagai, Y., Tanaka, A., Matsuda, A., Oida, K., Jung, K., & Matsuda, H. (2013). The phosphoinositide 3-Kinase pathway is crucial for the growth of canine mast cell tumors. Journal of Veterinary Medical Science, 75(6), 791–794. https://doi.org/10.1292/jvms.12-0540

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