Global sensitivity analysis for a chronic myelogenous leukemia model

Abstract

The goal of this paper is to carry out a global sensitivity analysis applied to a mathematical model for chronic myelogenous leukemia (CML) dynamics with T cell interaction. The interaction mechanism between naïve T cells, effector T cells, and CML cancer cells in the body is modeled by a system of ordinary differential equations which defines rates of variation for the three cell populations. We explain how to globally analyse the sensitivity of this complex system by means of two graphical objects: the sensitivity heat map and the parameter sensitivity spectrum.